| 英文名稱(chēng) | Triptolide |
|---|---|
| 中文名稱(chēng) | 雷公藤甲素/雷公藤多甙/雷公藤內酯醇/雷藤素甲 |
| CAS號 | 38748-32-2 |
| 分子式 | C20H24O6 |
| 分子量 | 360.4 |
| 外觀(guān) | 白色粉末 |
| 熔點(diǎn) | 226-227 °C |
| 沸點(diǎn) | 601.7±55.0 °C | Condition: Press: 760 Torr |
| 酸度系數pKa | 14.25±0.60 | Condition: Most Acidic Temp: 25 °C |
| 英文名稱(chēng) | Triptolide |
|---|---|
| 中文名稱(chēng) | 雷公藤甲素/雷公藤多甙/雷公藤內酯醇/雷藤素甲 |
| CAS號 | 38748-32-2 |
| 分子式 | C20H24O6 |
| 分子量 | 360.4 |
| 外觀(guān) | 白色粉末 |
| 熔點(diǎn) | 226-227 °C |
| 沸點(diǎn) | 601.7±55.0 °C | Condition: Press: 760 Torr |
| 酸度系數pKa | 14.25±0.60 | Condition: Most Acidic Temp: 25 °C |
WKQ-0000333
中文名稱(chēng)：雷公藤甲素
中文別名：雷公藤多甙；雷公藤內酯醇；雷藤素甲
英文名稱(chēng)：Triptolide
英文別名：Triptolide;(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one;(-)-Triptolide;NSC 163062;PG 490;Triptolid;[3bS-(3bα,4aα,5aR*,6β,6aβ,7aβ,7bα,8aR*,8bβ)]-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one;
分子式：C20H24O6
分子量：360.40
CAS號：38748-32-2
純度：HPLC≥98%
熔點(diǎn)：226-227 °C
沸點(diǎn)：601.7±55.0 °C | Condition: Press: 760 Torr
密度：1.48±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
酸系度數：14.25±0.60 | Condition: Most Acidic Temp: 25 °C
儲存條件：-20℃，干燥、避光、密封
規格：5mg10mg20mg50mg100mg500mg1g2g等應客戶(hù)需求包裝
供應單位：四川省維克奇生物科技有限公司
供應電話(huà)：028-81700200/4008005713
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| Identification and comparison of compounds in commercial Tripterygium wilfordii genus preparations with HPLC-QTOF/MS based on molecular networking and multivariate statistical analysis | ||
| 來(lái)源：SCI：JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 作者：Ge Xun | 備注：影響因子：3.571 |
| 引用描述 | ||
Spectra grade methanol and acetonitrile were purchased from Tedia (Fairfeild, USA). HPLC-grade formic acid was purchased from Kermel Chemical Reagent Co., Ltd. (Tianjin, China). Purified water was purchased from Wahaha (Zhejiang, Hangzhou, China). The reference standards triptolide, triptonide, triptophenolide, tripterifordin, wilforgine, wilforine, celastrol, demethylzeylasteral, wilforlide A, and pristimerin were purchased from Sichuan Weikeqi Biological Technology Co., Ltd. (Sichuan, China), and their purity was greater than 98%. Commercial Tripterygium glycosides tablets (TGT) were purchased from 13 factories (A-J), three batches of commercial Tripterygium wilfordii tablets (TWT) were from one factory (K), six different batches of commercial Tripterygium hypoglaucum hutch tablets (THHT) were purchased from two factories (L and M). | ||
| Hyperoside, a natural flavonoid compound, attenuates Triptolide-induced testicular damage by activating the Keap1-Nrf2 and SIRT1-PGC1α signalling pathway | ||
| 來(lái)源：SCI：JOURNAL OF PHARMACY AND PHARMACOLOGY | 作者：Wang Yucheng | 備注：影響因子：4.81 |
| 引用描述 | ||
Hyp (purity>99%) and TP (purity>99%) were acquired via Sichuan Weikeqi Biological Technology Co., Ltd. TP was dissolved in DMSO and then diluted 20 times with normal saline for intraperitoneal injection. | ||
| Synchronous Investigation of the Mechanism and Substance Basis of Tripterygium Glycosides Tablets on Anti-rheumatoid Arthritis and Hepatotoxicity | ||
| 來(lái)源：SCI：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 作者：Qian, Qi | 備注：影響因子：3.094 |
| 引用描述 | ||
Formic acid was HPLC grade obtained from Fisher (Fair Lawn, NJ, USA). Triptolide (Batch No. wkq18062706, purity?≥?98%), triptonide (Batch No. wkq18030812, purity?≥?98%), triptophenolide (Batch No. wkq18031301), wilforgine (Batch No. wkq18051009, purity?≥?98%), wilforine (Batch No. wkq18080604, purity?≥?98%), demethylzeylasteral (Batch No. wkq18031201, purity?≥?98%), and celastrol (Batch No. wkq18042604, purity?≥?98%) were purchased from Sichuan Weikeqi Biological Technology, Co., Ltd. (Sichuan, P.R. China). | ||
| Triptolide inhibits human immunodeficiency virus type 1 replication by promoting proteasomal degradation of Tat protein | ||
| 來(lái)源：SCI：Retrovirology | 作者：Wan, Zhitao | 備注：影響因子：4.767 |
| 引用描述 | ||
The compounds isolated from Chinese traditional herbs for the anti-HIV-1 drug screen were purchased from Sichuan Weikeqi Biological Technology Co., Ltd., China. The purity of the compound was ≥ 98%, as was determined by high-performance liquid chromatography analysis. The compound samples were solved in dimethyl sulfoxide (DMSO) at a concentration of 50 mM. | ||
| Aucubin, a natural iridoid glucoside, attenuates oxidative stress-induced testis injury by inhibiting JNK and CHOP activation via Nrf2 up-regulation | ||
| 來(lái)源：SCI：PHYTOMEDICINE | 作者：Bo Ma | 備注：影響因子：4.18 |
| 引用描述 | ||
DAPI 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium, MTT 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide and DMEM/F12 were obtained from Sigma (St. Louis, MO, USA). Aucubin (purity > 98%) and Triptolide (purity > 98%) were obtained from Weikeqi-Biotech Co., Ltd (Chengdu, China). The purity of Aucubin was detected using Waters alliance 2695-2998 HPLC. | ||
| Epigallocatechin-3-gallate Prevents Triptolide-Induced Hepatic Injury by Restoring the Th17/Treg Balance in Mice | ||
| 來(lái)源：SCI：AMERICAN JOURNAL OF CHINESE MEDICINE | 作者：Shu-Jing Yu | 備注：影響因子：2.959 |
| 引用描述 | ||
Purified TP and EGCG were purchased from Sichuan Weikeqi Biological Technology Co., Ltd (Sichuan, China), their purity was verified with the HPLC method (purity >98%) (Fig. 1). TP and EGCG were stored at 4C, prepared fresh prior to use, TP was dissolved in a small amount of absolute ethyl alcohol, and EGCG was dissolved in a small amount of DMSO | ||
| Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-κB pathway | ||
| 來(lái)源：SCI：INTERNATIONAL IMMUNOPHARMACOLOGY | 作者：Lian-Di Zhou | 備注：影響因子：2.956 |
| 引用描述 | ||
QE (purity > 98%) and TP (purity > 98%) were obtained from Sichuan Weikeqi Biological Technology Co., Ltd. (Sichuan, China). TLR4 protein antagonist Resatorvid (TAK-242) was purchased from Shanghai ZZBIO Co., Ltd. (Shanghai, China). Antibodies against TLR4, NF-κB, Foxp3 and β-actin were purchased from Wanleibio Co., Ltd. | ||
| Simultaneous determination of seven effective components of Tripterygium glycosides in human biological matrices by ultra performance liquid chromatography–triple quadrupole mass spectrometry | ||
| 來(lái)源：SCI：JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 作者：Xi Du | 備注：影響因子：2.813 |
| 引用描述 | ||
Triptolide (HPLC purity 99.49%), triptophenolide (HPLC purity 99.29%), celastrol (HPLC purity 98.33%), wilforgine (HPLC purity 99.53%), wilforine (HPLC purity 99.32%) and wilfortrine (HPLC purity 99.09%) were supplied by Weikeqi Biological Technology Co., Ltd (Sichuan, China). Wilfordine (HPLC purity 98%) was purchased from ChemFaces Biochemical Co., Ltd (Wuhan, China) and irbesartan (HPLC purity 99.8%) was used as internal standard (IS) and was obtained from National Institute for Food and Drug Control (Beijing, China). | ||
| Alteration of Androgen Receptor Protein Stability by Triptolide in LNCaP Cells | ||
| 來(lái)源：SCI：Medicina-Lithuania | 作者：Wei Li | 備注：影響因子：1.429 |
| 引用描述 | ||
Triptolide was purchased from Sichuan Weikeqi-Biotech Company (Chengdu, China); Cycloheximide (CHX) was purchased from Dalian Meilun Biotechnology (Dalian, China); Probenecid was purchased from Shanghai Aladdin Bio-Chem Technology Co., Ltd. (Shanghai, China); A23187 was purchased from BioVision, Inc. (Milpitas, CA, USA), BAPTA-AM was purchased from Selleck Chemicals | ||
